Does the early administration of tranexamic acid (TXA), compared with placebo, reduce death from bleeding in women with post-partum haemorrhage (PPH)?
Tranexamic acid may be beneficial in reducing the risk of death due to post-partum haemorrhage. The study has some significant methodological limitations, including a change in power calculation and hypothesis after it was commenced, as well as a low fragility index. On the basis of it being cheap with a good safety profile in this study, consider giving tranexamic early in post-partum haemorrhage. Early resuscitation, management of coagulopathy and surgical assistance with source control, are the most important interventions.
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